Crosstalk from Notch%20signaling%20pathway to Toll-like%20receptor%20signaling%20pathway
Attribute Name | Description |
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Pathway A | The name of the upstream (first) pathway in a pair of crosstalking pathways. |
Pathway B | The name of the downstream (second) pathway in a pair of crosstalking pathways. |
Pubmed Query | The string used as a structured query in PubMed that returned the recorded PMID as a result. |
PMID | The PubMed identifier for the reported publication. |
Crosstalk | yes, if Pathway A elicits a downstream transcriptional response in Pathway B. |
Transcriptional | yes, if the crosstalk is transcriptional. |
Regulation type | The downstream effect on Pathway B. This attribute can take one of the following two values:
|
Molecule A* | The molecule in Pathway A responsible for mediating crosstalk to Pathway B. |
Molecule A Identifier | Unique identifier for Molecule A in the namespace recorded in "Molecule A Source", e.g., the UniProt ID of a protein. |
Molecule A Source | The name of database that the value in "Molecule A Identifier" comes from, e.g., "UniProt" if the molecule is a protein. |
Molecule B* | The molecule in Pathway B responsible for mediating crosstalk from Pathway A. |
Molecule B Identifier | Unique identifier for Molecule B in the namespace recorded in "Molecule B Source", e.g., the UniProt ID of a protein. |
Molecule B Source | The name of database that the value in "Molecule B Identifier" comes from, e.g., "UniProt" if the molecule is a protein. |
Species | The name of the species in which the crosstalk was observed. |
Tissue | The name of the tissue or cell line in which the crosstalk was observed. |
BTO ID | The BRENDA Tissue Ontology (BTO) Identifier of the tissue or cell line in which the crosstalk was observed. |
Condition | Notes on the experimental condition in the publication. |
Sentence from paper | The sentence in the publication supporting the crosstalk. We record a sentence only if it states that Pathway A increases or decreases Pathway B signaling. The sentence may also include information about the proteins or genes responsible for mediating the crosstalk. |
Misleading evidence for crosstalk | A sentence in the paper that appears to support evidence for crosstalk when the study does not conclude there is crosstalk. |
Additional notes | A curator's notes that may provide rationale for the values recorded for the attributes. |
*This attribute may represent either an individual molecule or several molecules. We use the following syntax for this attribute.
- colon (:): The molecules participate in the complex, e.g., SMAD3:SMAD4 in the case of crosstalk from the TGF-beta signaling pathway to the Hippo signaling pathway (the complex consisting of SMAD3 and SMAD4 mediates this crosstalk).
- slash (/): Either of the molecules can mediate the crosstalk, e.g., YAP1/WWTR1 for the same pair of pathways (YAP1 or WWTR1 can mediate the crosstalk).
- comma (,): All the molecules are required for the crosstalk but they do not form a complex, e.g., TSC2,RPTOR for the crosstalk from the MAPK signaling pathway to the mTOR signaling pathway (both TSC2 and RPTOR act as mediators).
- brackets ([]): If we cannot identify the specific molecule, we record all molecules in the family, e.g., [TEAD1/TEAD2/TEAD3/TEAD4]. In this case, the publication only listed the protein TEAD as mediating the crosstalk (from the Hippo signaling pathway to the Wnt signaling pathway).