650

curated pathway pairs

345

crosstalking pathway pairs

1697

curated publications

Pathway pairs (A, B) where A activates B and A inhibits B using the same protein

	Pathway pairs	Proteins
1	mTOR signaling pathway Hippo signaling pathway	Mtor
2	NF-kappa B signaling pathway Jak-STAT signaling pathway	STAT3,TRAF6
3	NF-kappa B signaling pathway HIF-1 signaling pathway	HIF1A
4	HIF-1 signaling pathway Wnt signaling pathway	APC,HIF1A
5	HIF-1 signaling pathway Estrogen signaling pathway	HIF1A,ESR1
6	HIF-1 signaling pathway Notch signaling pathway	NOTCH1,HIF1A
7	TNF signaling pathway HIF-1 signaling pathway	TNF,HIF1A
8	Insulin signaling pathway Wnt signaling pathway	CTNNB1
9	Adipocytokine signaling pathway Insulin signaling pathway	LEP
10	Hippo signaling pathway Wnt signaling pathway	YAP1,DVL1,DVL2,CTNNB1,DVL3,WWTR1
11	TGF-beta signaling pathway Melanogenesis	TYR
12	Adherens junction Hippo signaling pathway	yki
13	Notch signaling pathway VEGF signaling pathway	FLT1
14	Wnt signaling pathway HIF-1 signaling pathway	CTNNB1
15	Estrogen signaling pathway Notch signaling pathway	NOTCH1
16	MAPK signaling pathway Melanogenesis	MAPK3,MITF
17	GnRH signaling pathway Apoptosis	CASP3

Pathway pairs (A, B) where A activates B and B activates A using the same protein

	Pathway pairs	Proteins
1	Adherens junction mTOR signaling pathway	MTOR
2	Notch signaling pathway VEGF signaling pathway	DLL4
3	TNF signaling pathway Toll-like receptor signaling pathway	TNF
4	Notch signaling pathway Toll-like receptor signaling pathway	Tlr5
5	Hedgehog signaling pathway NF-kappa B signaling pathway	SHH
6	NF-kappa B signaling pathway TNF signaling pathway	Rela
7	HIF-1 signaling pathway NF-kappa B signaling pathway	HIF1A
8	HIF-1 signaling pathway Wnt signaling pathway	HIF1A
9	Estrogen signaling pathway HIF-1 signaling pathway	ESR1,HIF1A
10	HIF-1 signaling pathway TGF-beta signaling pathway	TGFB1,HIF1A
11	Melanogenesis Wnt signaling pathway	CTNNB1
12	Estrogen signaling pathway TNF signaling pathway	TNF,ESR1
13	Insulin signaling pathway Wnt signaling pathway	Lrp6,Lrp5,Gcgr
14	Adipocytokine signaling pathway Insulin signaling pathway	IGF1
15	Hippo signaling pathway Insulin signaling pathway	yki
16	Adipocytokine signaling pathway Estrogen signaling pathway	LEPR,ESR1
17	Estrogen signaling pathway Hedgehog signaling pathway	SHH,ESR1
18	Jak-STAT signaling pathway Notch signaling pathway	STAT3
19	Thyroid hormone synthesis Wnt signaling pathway	CTNNB1
20	Hippo signaling pathway TGF-beta signaling pathway	YAP1
21	Adherens junction Hippo signaling pathway	YAP1
22	ErbB signaling pathway TGF-beta signaling pathway	TGFB1
23	Notch signaling pathway TGF-beta signaling pathway	HES1,SMAD3
24	Progesterone-mediated oocyte maturation Prolactin signaling pathway	Pgr,Stat5a
25	MAPK signaling pathway Prolactin signaling pathway	Prl
26	Estrogen signaling pathway Wnt signaling pathway	ESR1

Pathway pairs (A, B) where A activates B and B inhibits A using the same protein

	Pathway pairs	Proteins
1	Notch signaling pathway VEGF signaling pathway	VEGFA
2	Jak-STAT signaling pathway Toll-like receptor signaling pathway	TLR4
3	NF-kappa B signaling pathway VEGF signaling pathway	VEGFA
4	Jak-STAT signaling pathway NF-kappa B signaling pathway	STAT3
5	HIF-1 signaling pathway NF-kappa B signaling pathway	HIF1A
6	HIF-1 signaling pathway Hippo signaling pathway	TAZ,HIF1A
7	HIF-1 signaling pathway Notch signaling pathway	NOTCH1,HIF1A
8	NF-kappa B signaling pathway TNF signaling pathway	RELA
9	Insulin signaling pathway mTOR signaling pathway	RPS6KB1
10	Hedgehog signaling pathway Insulin signaling pathway	SHH
11	Hedgehog signaling pathway Hippo signaling pathway	YAP1
12	Insulin signaling pathway TGF-beta signaling pathway	IGFBP3,TGFB1
13	GnRH signaling pathway TGF-beta signaling pathway	GNRH1
14	ErbB signaling pathway Notch signaling pathway	EGFR,ERBB2,NOTCH1
15	HIF-1 signaling pathway Wnt signaling pathway	HIF1A
16	Estrogen signaling pathway HIF-1 signaling pathway	ESR1,HIF1A
17	Estrogen signaling pathway Hippo signaling pathway	YAP1
18	ErbB signaling pathway Hippo signaling pathway	YAP1

Statistics

650

curated pathway pairs

345

crosstalking pathway pairs

1697

curated publications

Pathway pairs (A, B) where A activates B and A inhibits B using the same protein

Pathway pairs (A, B) where A activates B and B activates A using the same protein

Pathway pairs (A, B) where A activates B and B inhibits A using the same protein