Crosstalk from MAPK signaling pathway to Melanogenesis

List of curated literature with evidence for crosstalk from MAPK signaling pathway to Melanogenesis

Geranylgeranylacetone inhibits melanin synthesis via ERK activation in Mel-Ab cells.
- PubMed ID : 23792203
- Molecule in MAPK signaling pathway: Mapk3/Mapk1
- Species : Mus musculus
- Transcription : yes
- Molecule in Melanogenesis: Tyr,Mitf
- Tissue : Mel-Ab cell
- Regulation type : Inhibiting
- Sentence from paper : These findings suggest that activation of ERK by GGA reduces melanin synthesis in Mel-Ab cells through downregulation of MITF and tyrosinase expression.
Octaphlorethol A isolated from Ishige foliacea inhibits α-MSH-stimulated induced melanogenesis via ERK pathway in B16F10 melanoma cells.
- PubMed ID : 23810793
- Molecule in MAPK signaling pathway: MAPK3/MAPK1
- Species : Homo sapiens
- Transcription : no
- Molecule in Melanogenesis: MITF
- Tissue : melanoma cell
- Regulation type : Inhibiting
- Sentence from paper : It has been reported that ERK is an important regulator of melanogenesis because ERK activation induces MITF phosphorylation and its subsequent degradation, and thus reduces melanin synthesis
Additive effect of heat on the UVB-induced tyrosinase activation and melanogenesis via ERK/p38/MITF pathway in human epidermal melanocytes.
- PubMed ID : 24671267
- Molecule in MAPK signaling pathway: MAPK3
- Species : Homo sapiens
- Transcription : no
- Molecule in Melanogenesis: MITF
- Tissue : melanocyte
- Regulation type : Activating
- Sentence from paper : In addition, growing evidence has shown that MITF is activated by the mitogen-activated protein kinase (MAPK) signaling pathways, including extracellular signal-regulated kinases (ERK), c-jun N-terminal kinases (JNK) and p38 MAPK
Quercetin-3-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside suppresses melanin synthesis by augmenting p38 MAPK and CREB signaling pathways and subsequent cAMP down-regulation in murine melanoma cells.
- PubMed ID : 26586997
- Molecule in MAPK signaling pathway: p38 MAPK
- Transcription : unknown
- Molecule in Melanogenesis: MITF
- Tissue : Not available
- Regulation type : Inhibiting
- Sentence from paper : Taken together, the suppressive effects of QCGG on melanogenesis may involve down-regulation of MITF and its downstream signaling pathway via phosphorylation of p38 MAPK and CREB along with reduced cAMP levels.

Molecules mediating the crosstalk

Molecule in MAPK signaling pathway	Molecule in Melanogenesis	Tissue	Species	PubMed Identifier
Mapk3/Mapk1	Tyr,Mitf	Mel-Ab cell	Mus musculus	23792203
MAPK3/MAPK1	MITF	melanoma cell	Homo sapiens	23810793
MAPK3	MITF	melanocyte	Homo sapiens	24671267
p38 MAPK	MITF	Not available	Not available	26586997

Note: We direct each interaction from the molecule in the first pathway to the molecule in the second pathway. The direction of the interaction does not imply that the first molecule regulates the second molecule or that they directly interact. Hence, the interactions in this network may be indirect and may not indicate any mechanism.

Attribute Name	Description
Pathway A	The name of the upstream (first) pathway in a pair of crosstalking pathways.
Pathway B	The name of the downstream (second) pathway in a pair of crosstalking pathways.
Pubmed Query	The string used as a structured query in PubMed that returned the recorded PMID as a result.
PMID	The PubMed identifier for the reported publication. We recorded "NO_RESULTS_FOR_PUBMED_QUERY" as a dummy PMID when the PubMed query returned no results.
Crosstalk	yes, if Pathway A elicits a downstream transcriptional response in Pathway B. no, otherwise.
Transcriptional	yes, if the crosstalk is transcriptional. no, otherwise.
Regulation type	The downstream effect on Pathway B. This attribute can take one of the following two values: Activating: Stimulation of Pathway A up-regulates a gene or activates a protein that is representative of Pathway B. Inhibiting: Stimulation of Pathway A down-regulates a gene or inhibits a protein that is representative of Pathway B.
Molecule A^*	The molecule in Pathway A responsible for mediating crosstalk to Pathway B.
Molecule A Identifier	Unique identifier for Molecule A in the namespace recorded in "Molecule A Source", e.g., the UniProt ID of a protein.
Molecule A Source	The name of database that the value in "Molecule A Identifier" comes from, e.g., "UniProt" if the molecule is a protein.
Molecule B^*	The molecule in Pathway B responsible for mediating crosstalk from Pathway A.
Molecule B Identifier	Unique identifier for Molecule B in the namespace recorded in "Molecule B Source", e.g., the UniProt ID of a protein.
Molecule B Source	The name of database that the value in "Molecule B Identifier" comes from, e.g., "UniProt" if the molecule is a protein.
Species	The name of the species in which the crosstalk was observed.
Tissue	The name of the tissue or cell line in which the crosstalk was observed.
BTO ID	The BRENDA Tissue Ontology (BTO) Identifier of the tissue or cell line in which the crosstalk was observed.
Condition	Notes on the experimental condition in the publication.
Sentence from paper	The sentence in the publication supporting the crosstalk. We record a sentence only if it states that Pathway A increases or decreases Pathway B signaling. The sentence may also include information about the proteins or genes responsible for mediating the crosstalk.
Misleading evidence for crosstalk	A sentence in the paper that appears to support evidence for crosstalk when the study does not conclude there is crosstalk.
Additional notes	A curator's notes that may provide rationale for the values recorded for the attributes.

*This attribute may represent either an individual molecule or several molecules. We use the following syntax for this attribute.

colon (:): The molecules participate in the complex, e.g., SMAD3:SMAD4 in the case of crosstalk from the TGF-beta signaling pathway to the Hippo signaling pathway (the complex consisting of SMAD3 and SMAD4 mediates this crosstalk).
slash (/): Either of the molecules can mediate the crosstalk, e.g., YAP1/WWTR1 for the same pair of pathways (YAP1 or WWTR1 can mediate the crosstalk).
comma (,): All the molecules are required for the crosstalk but they do not form a complex, e.g., TSC2,RPTOR for the crosstalk from the MAPK signaling pathway to the mTOR signaling pathway (both TSC2 and RPTOR act as mediators).
brackets ([]): If we cannot identify the specific molecule, we record all molecules in the family, e.g., [TEAD1/TEAD2/TEAD3/TEAD4]. In this case, the publication only listed the protein TEAD as mediating the crosstalk (from the Hippo signaling pathway to the Wnt signaling pathway).

Crosstalk from MAPK signaling pathway to Melanogenesis

Geranylgeranylacetone inhibits melanin synthesis via ERK activation in Mel-Ab cells.

Octaphlorethol A isolated from Ishige foliacea inhibits α-MSH-stimulated induced melanogenesis via ERK pathway in B16F10 melanoma cells.

Additive effect of heat on the UVB-induced tyrosinase activation and melanogenesis via ERK/p38/MITF pathway in human epidermal melanocytes.

Quercetin-3-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside suppresses melanin synthesis by augmenting p38 MAPK and CREB signaling pathways and subsequent cAMP down-regulation in murine melanoma cells.