Crosstalk from Jak-STAT signaling pathway to NF-kappa B signaling pathway
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB.
- Sentence from paper : P-STAT3 and P-p65 form a complex following stimulation of cells with both IL-1 and IL-6, after which STAT3 interacts with nonconsensus sequences at the 3â€™ boundary of kB element of the SAA promoter to enhance transcription
Note: We direct each interaction from the molecule in the first pathway to the molecule in the second pathway. The direction of the interaction does not imply that the first molecule regulates the second molecule or that they directly interact. Hence, the interactions in this network may be indirect and may not indicate any mechanism.