Crosstalk from Hippo signaling pathway to Wnt signaling pathway

List of curated literature with evidence for crosstalk from Hippo signaling pathway to Wnt signaling pathway

  • The Hippo pathway regulates Wnt/beta-catenin signaling.

    • PubMed ID : 20412773
    • Molecule in Hippo signaling pathway: Wwtr1
    • Species : Mus musculus
    • Transcription : no

    • Molecule in Wnt signaling pathway: Wnt3a
    • Tissue : kidney
    • Regulation type : Activating
    • Sentence from paper : Quantitative real-time PCR analysis revealed that knockdown of TAZ in MDA-MB-231 cells enhanced Wnt3A-induced AXIN2, NKD1, and TNFRSF19 expression

  • Crossroads of Wnt and Hippo in epithelial tissues.

    • PubMed ID : 23607968
    • Molecule in Hippo signaling pathway: YAP1/WWTR1
    • Species : Homo sapiens
    • Transcription : yes
    • Sentence from paper : Two pathways known to be important for epithelial development and homeostasis are the Wnt and Hippo pathways and there is accumulating evidence that the Hippo cascade engages in crosstalk with Wnt signaling in epithelial tissues

  • What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease.

    • PubMed ID : 23792172
    • Molecule in Hippo signaling pathway: YAP1/WWTR1
    • Species : Homo sapiens
    • Transcription : no
    • Sentence from paper : YAP/TAZ can inhibit Wnt signaling through inhibition of Dvl in the cytoplasm(TAZ) or in the nucleus(YAP) or sytoplasmic separation of beta-catenin (YAP)

  • What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease.

    • PubMed ID : 23792172
    • Molecule in Hippo signaling pathway: YAP1/WWTR1
    • Species : Homo sapiens
    • Transcription : no

    • Molecule in Wnt signaling pathway: CTNNB1
    • Tissue : eye
    • Regulation type : Inhibiting
    • Sentence from paper : YAP/TAZ can inhibit Wnt signaling through inhibition of Dvl in the cytoplasm(TAZ) or in the nucleus(YAP) or sytoplasmic separation of beta-catenin (YAP)

  • What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease.

    • PubMed ID : 23792172
    • Molecule in Hippo signaling pathway: YAP1
    • Species : Homo sapiens
    • Transcription : yes
    • Sentence from paper : YAP/TAZ can inhibit Wnt signaling through inhibition of Dvl in the cytoplasm(TAZ) or in the nucleus(YAP) or sytoplasmic separation of beta-catenin (YAP)

  • What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease.

    • PubMed ID : 23792172
    • Molecule in Hippo signaling pathway: YAP1
    • Species : Homo sapiens
    • Transcription : no

    • Molecule in Wnt signaling pathway: CTNNB1
    • Tissue : eye
    • Regulation type : Inhibiting
    • Sentence from paper : Alternatively, YAP can encourages the transcriptional activity of beta-catenin

  • [Crosstalk of Hippo/YAP and Wnt/β-catenin pathways].

    • PubMed ID : 24846937
    • Molecule in Hippo signaling pathway: YAP1
    • Species : Homo sapiens
    • Transcription : unknown
    • Sentence from paper : We discuss on the interactions between Wnt/beta-catenin and Hippo/YAP pathways

  • Wnt and FGF mediated epithelial-mesenchymal crosstalk during lung development.

    • PubMed ID : 25470458
    • Molecule in Hippo signaling pathway: YAP1/WWTR1
    • Species : Homo sapiens
    • Transcription : no

    • Molecule in Wnt signaling pathway: CTNNB1
    • Tissue : lung
    • Regulation type : Activating
    • Sentence from paper : One prime example of such crosstalk has already been briefly described above with the incorporation of cytoplasmic YAP/TAZ in the desctruction complex, where they are essential for beta-catenin as well as TAZ degradation by recruiting beta-TrCP

Molecules mediating the crosstalk
Molecule in Hippo signaling pathwayMolecule in Wnt signaling pathwayTissueSpeciesPubMed Identifier
Wwtr1Wnt3akidneyMus musculus20412773
YAP1/WWTR1[TEAD1/TEAD2/TEAD3/TEAD4]epitheliumHomo sapiens23607968
YAP1/WWTR1[DVL1/DVL2/DVL3]eyeHomo sapiens23792172
YAP1/WWTR1CTNNB1eyeHomo sapiens23792172
YAP1[DVL1/DVL2/DVL3]eyeHomo sapiens23792172
YAP1CTNNB1eyeHomo sapiens23792172
YAP1CTNNB1acute lymphoblastic leukemia cellHomo sapiens24846937
YAP1/WWTR1CTNNB1lungHomo sapiens25470458

Note: "Unknown" indicates that the molecule has not been identified.

Note: We direct each interaction from the molecule in the first pathway to the molecule in the second pathway. The direction of the interaction does not imply that the first molecule regulates the second molecule or that they directly interact. Hence, the interactions in this network may be indirect and may not indicate any mechanism.

Attribute NameDescription
Pathway A

The name of the upstream (first) pathway in a pair of crosstalking pathways.

Pathway B

The name of the downstream (second) pathway in a pair of crosstalking pathways.

Pubmed Query

The string used as a structured query in PubMed that returned the recorded PMID as a result.

PMID

The PubMed identifier for the reported publication.
We recorded "NO_RESULTS_FOR_PUBMED_QUERY" as a dummy PMID when the PubMed query returned no results.

Crosstalk

yes, if Pathway A elicits a downstream transcriptional response in Pathway B.
no, otherwise.

Transcriptional

yes, if the crosstalk is transcriptional.
no, otherwise.

Regulation type

The downstream effect on Pathway B. This attribute can take one of the following two values:

  • Activating: Stimulation of Pathway A up-regulates a gene or activates a protein that is representative of Pathway B.
  • Inhibiting: Stimulation of Pathway A down-regulates a gene or inhibits a protein that is representative of Pathway B.
Molecule A*

The molecule in Pathway A responsible for mediating crosstalk to Pathway B.

Molecule A Identifier

Unique identifier for Molecule A in the namespace recorded in "Molecule A Source", e.g., the UniProt ID of a protein.

Molecule A Source

The name of database that the value in "Molecule A Identifier" comes from, e.g., "UniProt" if the molecule is a protein.

Molecule B*

The molecule in Pathway B responsible for mediating crosstalk from Pathway A.

Molecule B Identifier

Unique identifier for Molecule B in the namespace recorded in "Molecule B Source", e.g., the UniProt ID of a protein.

Molecule B Source

The name of database that the value in "Molecule B Identifier" comes from, e.g., "UniProt" if the molecule is a protein.

Species

The name of the species in which the crosstalk was observed.

Tissue

The name of the tissue or cell line in which the crosstalk was observed.

BTO ID

The BRENDA Tissue Ontology (BTO) Identifier of the tissue or cell line in which the crosstalk was observed.

Condition

Notes on the experimental condition in the publication.

Sentence from paper

The sentence in the publication supporting the crosstalk. We record a sentence only if it states that Pathway A increases or decreases Pathway B signaling. The sentence may also include information about the proteins or genes responsible for mediating the crosstalk.

Misleading evidence for crosstalk

A sentence in the paper that appears to support evidence for crosstalk when the study does not conclude there is crosstalk.

Additional notes

A curator's notes that may provide rationale for the values recorded for the attributes.

*This attribute may represent either an individual molecule or several molecules. We use the following syntax for this attribute.

  • colon (:): The molecules participate in the complex, e.g., SMAD3:SMAD4 in the case of crosstalk from the TGF-beta signaling pathway to the Hippo signaling pathway (the complex consisting of SMAD3 and SMAD4 mediates this crosstalk).
  • slash (/): Either of the molecules can mediate the crosstalk, e.g., YAP1/WWTR1 for the same pair of pathways (YAP1 or WWTR1 can mediate the crosstalk).
  • comma (,): All the molecules are required for the crosstalk but they do not form a complex, e.g., TSC2,RPTOR for the crosstalk from the MAPK signaling pathway to the mTOR signaling pathway (both TSC2 and RPTOR act as mediators).
  • brackets ([]): If we cannot identify the specific molecule, we record all molecules in the family, e.g., [TEAD1/TEAD2/TEAD3/TEAD4]. In this case, the publication only listed the protein TEAD as mediating the crosstalk (from the Hippo signaling pathway to the Wnt signaling pathway).