Crosstalk from Hippo signaling pathway to TGF-beta signaling pathway
Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling.
- Sentence from paper : We have identified YAP65 as a novel Smad7-interacting protein involved in the association of Smad7 to activated TRI.
Crosstalk between Hippo and TGFβ: Subcellular Localization of YAP/TAZ/Smad Complexes.
- Molecule in TGF-beta signaling pathway: SMAD2:SMAD3
- Tissue : HaCaT cell
- Regulation type : Unknown
- Sentence from paper : Both these mechanisms may function to control TGFβ signaling under specific context-dependent circumstances, regulating cytoplasmic/nuclear shuttling of Smads in a cell-density-dependent manner.
Note: We direct each interaction from the molecule in the first pathway to the molecule in the second pathway. The direction of the interaction does not imply that the first molecule regulates the second molecule or that they directly interact. Hence, the interactions in this network may be indirect and may not indicate any mechanism.