Crosstalk from HIF-1 signaling pathway to NF-kappa B signaling pathway
NFκB and HIF display synergistic behaviour during hypoxic inflammation.
- Molecule in NF-kappa B signaling pathway: PTGS2
- Tissue : HEK-293 cell
- Regulation type : Activating
- Sentence from paper : Furthermore, we demonstrate synergistic activity between these two transcription factors on the regulation of the COX-2 promoter, implicating a co-ordinated role for both HIF and NFκB in the expression of COX-2 in hypoxic inflammation.
Note: We direct each interaction from the molecule in the first pathway to the molecule in the second pathway. The direction of the interaction does not imply that the first molecule regulates the second molecule or that they directly interact. Hence, the interactions in this network may be indirect and may not indicate any mechanism.