Crosstalk from Estrogen signaling pathway to TNF signaling pathway
List of curated literature with evidence for crosstalk from Estrogen signaling pathway to TNF signaling pathway
Tumor necrosis factor-α activates estrogen signaling pathways in endometrial epithelial cells via estrogen receptor α.
- Molecule in TNF signaling pathway: ESR1
- Tissue : Ishikawa cell
- Regulation type : Activating
- Sentence from paper : Co-treatment with a pure ER antagonist resulted in an inhibition of this TNF-α-induced ERE luciferase activity and gene expression, demonstrating that this cytokine signals through ERs.
Estrogen is a novel regulator of Tnfaip1 in mouse hippocampus.
- Molecule in TNF signaling pathway: Tnfaip1
- Tissue : hippocampus
- Regulation type : Activating
- Sentence from paper : Additional experiments demonstrated the existence of a binding site of ERβ in the Tnfaip1 promoter region, and that ERβ was able to upregulate Tnfaip1 expression.
17β-Estradiol inhibits TNF-α-induced proliferation and migration of vascular smooth muscle cells via suppression of TRAIL.
- PubMed ID : 26878683
- Molecule in Estrogen signaling pathway: ESR1
- Species : unknown
- Transcription : yes
- Molecule in TNF signaling pathway: unknown
- Tissue : vascular smooth muscle cell
- Regulation type : Inhibiting
- Sentence from paper : 17β-estradiol (E2) inhibited TRAIL expression under TNF-α stimulation in a time- and concentration-dependent manner.
Note: We direct each interaction from the molecule in the first pathway to the molecule in the second pathway. The direction of the interaction does not imply that the first molecule regulates the second molecule or that they directly interact. Hence, the interactions in this network may be indirect and may not indicate any mechanism.