Crosstalk from Hedgehog signaling pathway to Insulin signaling pathway
The insulin-like growth factor (IGF) receptor type 1 (IGF1R) as an essential component of the signalling network regulating neurogenesis.
- Sentence from paper : In addition, the interaction between Shh and IGF1R pathways may be bi-directional as suggested by the ability of Shh to stabilise IRS-1 by interfering with its mTOR-mediated degradation
Cooperation between Shh and IGF-I in promoting myogenic proliferation and differentiation via the MAPK/ERK and PI3K/Akt pathways requires Smo activity.
- Sentence from paper : IGF-IR was found to associate with Smo in response to IGF-I
Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels.
- Sentence from paper : Indeed, two active GLI3 binding sites in the promoter region of the Igf1 gene have already been identified
|Molecule in Hedgehog signaling pathway||Molecule in Insulin signaling pathway||Tissue||Species||PubMed Identifier|
|SHH||IRS1||central nervous system||Homo sapiens||19714501|
Note: "Unknown" indicates that the molecule has not been identified.
Note: We direct each interaction from the molecule in the first pathway to the molecule in the second pathway. The direction of the interaction does not imply that the first molecule regulates the second molecule or that they directly interact. Hence, the interactions in this network may be indirect and may not indicate any mechanism.
XTalkDB does not contain any molecules mediating the crosstalk.
The name of the upstream (first) pathway in a pair of crosstalking pathways.
The name of the downstream (second) pathway in a pair of crosstalking pathways.
The string used as a structured query in PubMed that returned the recorded PMID as a result.
The PubMed identifier for the reported publication.
yes, if Pathway A elicits a downstream transcriptional response in Pathway B.
yes, if the crosstalk is transcriptional.
The downstream effect on Pathway B. This attribute can take one of the following two values:
The molecule in Pathway A responsible for mediating crosstalk to Pathway B.
|Molecule A Identifier|
Unique identifier for Molecule A in the namespace recorded in "Molecule A Source", e.g., the UniProt ID of a protein.
|Molecule A Source|
The name of database that the value in "Molecule A Identifier" comes from, e.g., "UniProt" if the molecule is a protein.
The molecule in Pathway B responsible for mediating crosstalk from Pathway A.
|Molecule B Identifier|
Unique identifier for Molecule B in the namespace recorded in "Molecule B Source", e.g., the UniProt ID of a protein.
|Molecule B Source|
The name of database that the value in "Molecule B Identifier" comes from, e.g., "UniProt" if the molecule is a protein.
The name of the species in which the crosstalk was observed.
The name of the tissue or cell line in which the crosstalk was observed.
The BRENDA Tissue Ontology (BTO) Identifier of the tissue or cell line in which the crosstalk was observed.
Notes on the experimental condition in the publication.
|Sentence from paper|
The sentence in the publication supporting the crosstalk. We record a sentence only if it states that Pathway A increases or decreases Pathway B signaling. The sentence may also include information about the proteins or genes responsible for mediating the crosstalk.
|Misleading evidence for crosstalk|
A sentence in the paper that appears to support evidence for crosstalk when the study does not conclude there is crosstalk.
A curator's notes that may provide rationale for the values recorded for the attributes.
*This attribute may represent either an individual molecule or several molecules. We use the following syntax for this attribute.
- colon (:): The molecules participate in the complex, e.g., SMAD3:SMAD4 in the case of crosstalk from the TGF-beta signaling pathway to the Hippo signaling pathway (the complex consisting of SMAD3 and SMAD4 mediates this crosstalk).
- slash (/): Either of the molecules can mediate the crosstalk, e.g., YAP1/WWTR1 for the same pair of pathways (YAP1 or WWTR1 can mediate the crosstalk).
- comma (,): All the molecules are required for the crosstalk but they do not form a complex, e.g., TSC2,RPTOR for the crosstalk from the MAPK signaling pathway to the mTOR signaling pathway (both TSC2 and RPTOR act as mediators).
- brackets (): If we cannot identify the specific molecule, we record all molecules in the family, e.g., [TEAD1/TEAD2/TEAD3/TEAD4]. In this case, the publication only listed the protein TEAD as mediating the crosstalk (from the Hippo signaling pathway to the Wnt signaling pathway).